Vitamins – Vitamin K1 (Phylloquinone) – part 9

Phylloquinone is a polycyclic aromatic ketone, based on 2-methyl1,4-naphthoquinone, with a 3-phytyl substituent.

It is a fat-soluble vitamin that is stable to air and moisture but decomposes in sunlight. It is found naturally in a wide variety of green plants, particularly leaves, since it functions as an electron acceptor during photosynthesis, forming part of the electron transport chain of Photosystem I.

Phylloquinone
Identifiers
CAS number 84-80-0 
PubChem 4812
ChemSpider 4447652 
UNII A034SE7857 
DrugBank DB01022
ChEBI CHEBI:18067 
ChEMBL CHEMBL1550 
ATC code B02BA01
Jmol-3D images Image 1
Properties
Molecular formula C31H46O2
Molar mass 450.7 g mol−1

Terminology

It is often called vitamin K1, phytomenadione or phytonadione. Sometimes a distinction is made with phylloquinone considered natural and phytonadione considered synthetic.

A stereoisomer of phylloquinone is called vitamin k1 (note the difference in capitalization).

Biochemistry

Phylloquinone is an electron acceptor during photosynthesis, forming part of the electron transport chain of Photosystem I.

Its best-known function in animals is as a cofactor in the formation of coagulation factors II (prothrombin), VII, IX, and X by the liver. It is also required for the formation of anticoagulant factors protein C and S. It is commonly used to treat warfarin toxicity, and as an antidote for coumatetralyl.

Vitamin K is also required for bone protein formation.

source: http://en.wikipedia.org/wiki/Phylloquinone

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